abstract：:Necrotizing sarcoid granulomatosis (NSG) is characterized by pulmonary nodular infiltrates, a typical histology, and a benign clinical course. The etiology and pathogenesis of the disease are still unknown. In childhood, it is extremely rare, with only three reported cases so far. Here we report on an 8-year-old girl,...

journal_title：Pediatric pulmonology

authors： Heinrich D,Gordjani N,Trusen A,Marx A,Hebestreit H

更新日期：2003-05-01 00:00:00

abstract：:Until the year 2000, systematic cystic fibrosis (CF) neonatal screening was only performed in a few regions of France. The Brittany region began in 1989, but not the neighboring region of Loire-Atlantique. The present study compares the clinical evolution of both affected populations 10 years after screening was start...

journal_title：Pediatric pulmonology

authors： Siret D,Bretaudeau G,Branger B,Dabadie A,Dagorne M,David V,de Braekeleer M,Moisan-Petit V,Picherot G,Rault G,Storni V,Roussey M

更新日期：2003-05-01 00:00:00

abstract：:We assessed the safety and use of induced sputum (IS) in children with cystic fibrosis (CF). Forty-eight children (19 males) with CF, mean age 12.6 (range, 7.3-17.0) years and median forced expired volume in 1 sec (FEV(1)) 48% (range, 14-77%) predicted were recruited. Patients spontaneously expectorated sputum and the...

journal_title：Pediatric pulmonology

authors： Suri R,Marshall LJ,Wallis C,Metcalfe C,Shute JK,Bush A

更新日期：2003-04-01 00:00:00

abstract：:It has been suggested that cystic fibrosis (CF) patients harboring multiresistant (MR) Pseudomonas aeruginosa (PA) should be seen in separate clinics. The aim of this study was to test the feasibility of this by longitudinally studying the consistency of isolates of MRPA in individuals. We analyzed all respiratory tra...

journal_title：Pediatric pulmonology

authors： Davies G,McShane D,Davies JC,Bush A

更新日期：2003-04-01 00:00:00

abstract：:The impulse oscillometry system (IOS) was introduced as a new technique to assess airflow obstruction in patients who are not able to perform forced breathing maneuvers, e.g., subjects with cerebral palsy or severe mental retardation, and young children. This study evaluates the sensitivity and specificity of IOS para...

journal_title：Pediatric pulmonology

authors： Vink GR,Arets HG,van der Laag J,van der Ent CK

更新日期：2003-03-01 00:00:00

abstract：:Multiresistance in Stenotrophomonas maltophilia limits the effectiveness of antimicrobial therapy for infections due to this organism. It can be of special concern in cystic fibrosis (CF) patients due to frequent antimicrobial administration. The in vitro activity of 41 antimicrobial agents against 76 epidemiologicall...

journal_title：Pediatric pulmonology

authors： Cantón R,Valdezate S,Vindel A,Sánchez Del Saz B,Maíz L,Baquero F

更新日期：2003-02-01 00:00:00

abstract：:A microbe-specific diagnosis in community-acquired pneumonia (CAP) is difficult in children, and studies on nonspecific chest radiographic and host response markers have been inconsistent. Serum procalcitonin (PCT) is a newly recognized, promising marker for differentiating between bacterial and viral infections. Seru...

journal_title：Pediatric pulmonology

authors： Korppi M,Remes S,Heiskanen-Kosma T

更新日期：2003-01-01 00:00:00

abstract：:There is a subpopulation of asthmatic patients with a history of life-threatening asthma (LTA) who have a reduced perception of respiratory loads. The aim of this study was to determine if these patients have a reduced perception of both intrinsic and extrinsic loads. Children with asthma were classified into life-thr...

journal_title：Pediatric pulmonology

authors： Julius SM,Davenport KL,Davenport PW

更新日期：2002-12-01 00:00:00

abstract：:We report on a 1-month-old boy who presented with a "horseshoe" lung, complete "O" rings of the trachea, and an unusual course of the left pulmonary artery mimicking a left pulmonary artery sling. Computed tomography, cardiac catheterization, and bronchoscopy were performed to confirm the rare coexistence of these ano...

journal_title：Pediatric pulmonology

authors： Hwang HK,Chen MR,Chen SJ,Kao HA,Lee KS,Shih SL

更新日期：2002-11-01 00:00:00

abstract：:While the use of the raised volume rapid thoraco-abdominal compression (RVRTC) technique has been shown to provide new insights into airway and pulmonary pathophysiology in infants, and appears to resemble the spirometric techniques used in older subjects, there is as yet no consensus regarding measurement procedures,...

journal_title：Pediatric pulmonology

authors： Lum S,Hoo AF,Stocks J

更新日期：2002-11-01 00:00:00

abstract：:The efficacy and tolerability of high-dose salmeterol (100 mcg, BID) and albuterol (2.5 mg, BID) were compared with those of albuterol (2.5 mg, BID) in outpatients with cystic fibrosis in a randomized, double-blind, double-dummy, placebo-controlled, crossover study with both short- (4 weeks of each) and long-term (24 ...

journal_title：Pediatric pulmonology

authors： Hordvik NL,Sammut PH,Judy CG,Colombo JL

更新日期：2002-10-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a genetic disorder, with hypotonia being the predominant feature in infancy, and developmental delay, obesity, and behavioral problems becoming more prominent in childhood and adolescence. Children with this disorder frequently suffer from excessive daytime sleepiness and have a primary ...

journal_title：Pediatric pulmonology

authors： Nixon GM,Brouillette RT

更新日期：2002-09-01 00:00:00

abstract：:Pulmonary hemorrhage (PH) is a serious complication causing acute respiratory distress in the premature infant, and it is associated with significant mortality and morbidity. The role of inflammatory mediators in this condition is largely undefined. Serial tracheal aspirates (TA) were obtained at intervals from 65 mec...

journal_title：Pediatric pulmonology

authors： Baier RJ,Loggins J,Kruger TE

更新日期：2002-08-01 00:00:00

abstract：:Appropriate, regular exercise is of benefit to patients with cystic fibrosis (CF). As with other segments of the population, it has been difficult to devise exercise programs to which most patients will adhere for long periods of time. In healthy children, factors that are related to positive exercise compliance inclu...

journal_title：Pediatric pulmonology

authors： Prasad SA,Cerny FJ

更新日期：2002-07-01 00:00:00

abstract：:The purpose of the present study was to identify prognostic factors related to death in patients with cystic fibrosis (CF). Records of 127 patients with CF submitted to a systematic protocol were retrospectively reviewed. Prognostic factors associated with demographic, nutritional, clinical, and laboratory findings on...

journal_title：Pediatric pulmonology

authors： Oliveira MC,Reis FJ,Oliveira EA,Colosimo EA,Monteiro AP,Penna FJ

更新日期：2002-07-01 00:00:00

abstract：:This study was designed to collect data on the prevalence of respiratory syncytial virus (RSV) infection in Italy in infants hospitalized for lower respiratory tract infections, and to evaluate which of the recognized risk factors might be associated with disease severity. Thirty-two centers throughout Italy participa...

journal_title：Pediatric pulmonology

authors： Lanari M,Giovannini M,Giuffré L,Marini A,Rondini G,Rossi GA,Merolla R,Zuccotti GV,Salvioli GP,Investigators R.A.DA.R. Study Group.

更新日期：2002-06-01 00:00:00

abstract：:A continuous subcutaneous infusion of terbutaline (CSIT) was used to treat 8 children with chronic severe asthma who continued to experience frequent symptoms, despite treatment with regular oral prednisolone. Five patients experienced a symptomatic improvement from CSIT, leading to a reduction in regular medication. ...

journal_title：Pediatric pulmonology

authors： Payne DN,Balfour-Lynn IM,Biggart EA,Bush A,Rosenthal M

更新日期：2002-05-01 00:00:00

abstract：:Even though childhood asthma is assumed to comprise reversible airway obstruction, some children develop irreversible airway obstruction (not reversed by a bronchodilator or corticosteroids); this may be due to inflammation that has caused remodeling. Lately, it has been claimed that in the absence of treatment with i...

journal_title：Pediatric pulmonology

authors： König P

更新日期：2002-04-01 00:00:00

abstract：:Deficiency of mannose-binding lectin has been shown to be a risk factor for cystic fibrosis (CF) patients. We, therefore, decided to treat a patient with CF, mannose-binding lectin deficiency, severe bronchopulmonary Pseudomonas aeruginosa infection, and rapid deterioration of lung function with purified mannose-bindi...

journal_title：Pediatric pulmonology

authors： Garred P,Pressler T,Lanng S,Madsen HO,Moser C,Laursen I,Balstrup F,Koch C,Koch C

更新日期：2002-03-01 00:00:00

abstract：:The raised lung volume technique is increasingly used to measure forced expiratory maneuvers in infants. However, there is no consensus regarding the optimal airway inflation pressure (P(inf)) required for such maneuvers, or the influence of small changes in P(inf) within and between infants. The aim of this study was...

journal_title：Pediatric pulmonology

authors： Lum S,Hoo AF,Stocks J

更新日期：2002-02-01 00:00:00

abstract：:The prevalence and morbidity of asthma are growing problems that appear to affect urban populations and particularly impoverished centers disproportionately. Poor children are more likely to be hospitalized for asthma than nonpoor children, and are more likely to experience clinical and social dysfunction due to asthm...

journal_title：Pediatric pulmonology

authors： Shapiro GG,Stout JW

更新日期：2002-01-01 00:00:00

abstract：:The prognosis for patients with acute respiratory distress syndrome (ARDS) in adults and children has improved since its formal acceptance as a clinical entity in 1967. Because acute hypoxemic respiratory failure is the hallmark of acute lung injury and ARDS, the management of oxygenation is crucial. Physicians managi...

journal_title：Pediatric pulmonology

authors： Matthews BD,Noviski N

更新日期：2001-12-01 00:00:00

abstract：:A thorough understanding of the early natural history of cystic fibrosis (CF) lung disease is critical for the development of effective interventions in the youngest patients. We assessed the evolution of pulmonary infection, inflammation, and clinical course among 40 infants over a 2-year period through annual bronch...

journal_title：Pediatric pulmonology

authors： Rosenfeld M,Gibson RL,McNamara S,Emerson J,Burns JL,Castile R,Hiatt P,McCoy K,Wilson CB,Inglis A,Smith A,Martin TR,Ramsey BW

更新日期：2001-11-01 00:00:00

abstract：:Inhaled corticosteroids are commonly used in cystic fibrosis (CF), but there are few studies evaluating their safety in young children. We, therefore, prospectively administered beclomethasone diproprionate (BDP) to 12 clinically stable young children with CF to examine the safety of this therapy with respect to adren...

journal_title：Pediatric pulmonology

authors： Wojtczak HA,Kerby GS,Wagener JS,Copenhaver SC,Gotlin RW,Riches DW,Accurso FJ

更新日期：2001-10-01 00:00:00

abstract：:This study sought to determine if a clinical pathway developed and executed by specialists in pediatric asthma would reduce hospital costs and length of stay (LOS). The study design was a retrospective, nonrandomized, controlled trial. Subjects were children aged 2-18 years (N = 1,004) with a history of recurrent whee...

journal_title：Pediatric pulmonology

authors： Wazeka A,Valacer DJ,Cooper M,Caplan DW,DiMaio M

更新日期：2001-09-01 00:00:00

abstract：:We compared proliferation (growth) and differentiation (development) related proteins in normal and hypoplastic fetal murine lungs. The hypoplastic lungs were created in CD-1 fetal mice by nitrofen exposure (25 mg per pregnant mouse given intragastrically on gestational day 8 [Gd8]), as published earlier. The lungs we...

journal_title：Pediatric pulmonology

authors： Chinoy MR,Chi X,Cilley RE

更新日期：2001-08-01 00:00:00

abstract：:During the final prenatal period of fetal lung development in humans, important maturational processes occur, including the production of surfactant necessary to decrease surface tension at the air-liquid interface of the alveoli. During early gestation, the glucocorticoid receptor is expressed in the fetal lung, and ...

journal_title：Pediatric pulmonology

authors： Bolt RJ,van Weissenbruch MM,Lafeber HN,Delemarre-van de Waal HA

更新日期：2001-07-01 00:00:00

abstract：:We recently reported that prenatal glucocorticoid therapy is less effective at promoting an improvement in lung function in male than in female sheep. This observation, and the higher incidence of respiratory distress syndrome in human males, suggests that the male fetal lung may be less responsive to glucocorticoids ...

journal_title：Pediatric pulmonology

authors： Kovar J,Waddell BJ,Sly PD,Willet KE

更新日期：2001-07-01 00:00:00

abstract：:During the past five decades there has been increasing interest in the potential anti-inflammatory effects of macrolide antibiotics. Low-dose macrolide therapy has dramatically increased survival in patients with diffuse panbronchiolitis, a disease with many similarities to cystic fibrosis (CF). This has led to furthe...

journal_title：Pediatric pulmonology

authors： Jaffé A,Bush A

更新日期：2001-06-01 00:00:00

abstract：:To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days. Animals rece...

journal_title：Pediatric pulmonology

authors： Fabris VE,Pato MD,Belik J

更新日期：2001-05-01 00:00:00

abstract：:We enrolled 30 infants (median age 3 months, range 1-12 months), hospitalized for bronchiolitis in a randomized double-blind trial, to examine the efficacy and safety of nebulized epinephrine compared to salbutamol. Once admitted, patients were treated with either nebulized 0.5 mg of an 0.1% epinephrine solution (0.5 ...

journal_title：Pediatric pulmonology

authors： Bertrand P,Araníbar H,Castro E,Sánchez I

更新日期：2001-04-01 00:00:00

abstract：:Central ventilation disorders(1) and airway obstruction(2) with chronic hypoxemia are causally related to cor pulmonale. Pulmonary vascular resistance is often reversible, and hypoxic pulmonary hypertension often responds to treatment with supplemental oxygen. Oxygen therapy during sleep may be useful as a temporary p...

journal_title：Pediatric pulmonology

authors： Hoch B,Barth H

更新日期：2001-03-01 00:00:00

abstract：:For patients whose asthma remains in poor control necessitating high utilization of medical services, a referral to a specialized "center of excellence" is often considered. A decade ago, we evaluated our pediatric asthma program of long-term hospitalization (median stay of 75 days) and found significant decreases in ...

journal_title：Pediatric pulmonology

authors： Bratton DL,Price M,Gavin L,Glenn K,Brenner M,Gelfand EW,Klinnert MD

更新日期：2001-03-01 00:00:00

abstract：:The purpose of the study was to analyze the respiratory-dependent intraarterial blood pressure variations (pulsus paradoxus, PP) in intensive care unit patients with obstructive and restrictive pulmonary disease, and to evaluate the usefulness of PP for assessment of disease severity. One-minute paper recordings of ar...

journal_title：Pediatric pulmonology

authors： Frey B,Freezer N

更新日期：2001-02-01 00:00:00

abstract：:SUMMARY. Patients with idiopathic scoliosis are reported to have a restrictive pattern on pulmonary function tests. A case is presented of a teenage girl with juvenile idiopathic scoliosis who had evidence of airways obstruction in addition to restriction on pulmonary function tests (PFT). Examination of flow-volume l...

journal_title：Pediatric pulmonology

authors： Borowitz D,Armstrong D,Cerny F

更新日期：2001-01-01 00:00:00

abstract：:SUMMARY. The detection of early airway disease in infants with cystic fibrosis (CF) may lead to earlier intervention and an improved prognosis. We hypothesized that the ratio of maximal expiratory flows while breathing a mixture of helium and oxygen (heliox) and air, referred to as density dependence (DD), would ident...

journal_title：Pediatric pulmonology

authors： Davis S,Jones M,Kisling J,Howard J,Tepper RS

更新日期：2001-01-01 00:00:00

abstract：:The purpose of this report is to describe the College of American Pathologists sweat testing (SW) proficiency testing program for cystic fibrosis, to evaluate its impact on test performance, and to describe the current practice of sweat testing in North America. The study analyzed participant summary reports of the SW...

journal_title：Pediatric pulmonology

authors： LeGrys VA

更新日期：2000-12-01 00:00:00

abstract：:In children, pulmonary sequelae contribute to early and late morbidity after bone marrow transplantation (BMT). Between 1975-1999, we performed 152 BMTs in 138 pediatric patients with malignant and nonmalignant diseases. Allogenic bone marrow was used from 99 HLA identical siblings and from 23 other related or unrelat...

journal_title：Pediatric pulmonology

authors： Griese M,Rampf U,Hofmann D,Führer M,Reinhardt D,Bender-Götze C

更新日期：2000-11-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection can be severe in pediatric patients. Risk factors for severe disease include age less than 6 months, prematurity, preexisting heart or lung disease or malformations, gastroesophageal reflux, and immunodeficiency. The aim of the present study was to investigate the influence ...

journal_title：Pediatric pulmonology

authors： Trefny P,Stricker T,Baerlocher C,Sennhauser FH

更新日期：2000-10-01 00:00:00

abstract：:A new method that permits the measurement of adult-type maximal expiratory flow-volume curves and fractional lung volumes in sedated infants was recently described. The purpose of this study was to define the normal range for these new measures of pulmonary function in infants and young children. Measurements of force...

journal_title：Pediatric pulmonology

authors： Castile R,Filbrun D,Flucke R,Franklin W,McCoy K

更新日期：2000-09-01 00:00:00